:Recent neuroimaging research on disorders of consciousness provides direct evidence of covert consciousness otherwise not detected clinically in a subset of severely brain-injured patients. These findings have motivated strategic development of binary communication paradigms, from which researchers interpret voluntary modulations in brain activity to glean information about patients’ residual cognitive functions and emotions. The discovery of such responsiveness raises ethical and legal issues concerning the exercise of autonomy and capacity for decisionmaking on matters such as healthcare, involvement in research, and (...) end of life. These advances have generated demands for access to the technology against a complex background of continued scientific advancement, questions about just allocation of healthcare resources, and unresolved legal issues. Interviews with professionals whose work is relevant to patients with disorders of consciousness reveal priorities concerning further basic research, legal and policy issues, and clinical considerations. (shrink)

The proteasome family of proteases comprises oligomeric assemblies of very different symmetry. In different sizes, it features ring‐like oligomers with dihedral symmetry that allow the stacking of further rings of regulatory subunits as observed in the modular proteasome system, but also less symmetric helical assemblies. Comprehensive sequence and structural analyses of proteasome homologs reveal a parsimonious scenario of how symmetry may have emerged from a monomeric ancestral precursor and how it may have evolved throughout the proteasome family. The four characterized (...) representatives—ancestral β subunit (Anbu), HslV, betaproteobacterial proteasome homolog (BPH), and the 20S proteasome—are outlasting cornerstones in the family's evolutionary history, each marking a transition in symmetry. This article contextualizes the evolutionary and functional key aspects of these symmetry transitions, explaining how they facilitated the diversification and concurrent evolution of independent proteolytic systems side by side, each with its customized network of auxiliary interactors. -/- . (shrink)

Por razones de modificación en la estructura económica y política y ante la evidencia que el Estado fue retrayéndose de sus actividades de regulación y control sobre la vida política y social, comenzaron a crecer las llamadas "organizaciones sin fines de lucro". Nos encontramos con una coincidente proliferación de las ONG de diversos ámbitos durante décadas del '80 y '90 con diferentes objetivos, estructuras de instituirse y relacionarse, formas de relacionarse y subsistir que acompañan y son acompañadas de las normativas (...) tanto institucionales como nacionales. La impronta de fuerza que estas organizaciones sociales, llamadas ONG, y sus particulares dinámicas, no hizo más que estabilizar el imaginario de la omnipotencia y omnipresencia de los organismos internacionales de créditos, debido a que en su accionar también acentuaron las ineficiencias e ineficacias del Estado. La lectura que se intenta hacer es de vislumbrar lo que se escabulle en la construcción de las subjetividades sobre este esfuerzo mancomunado que la sociedad argentina realizó, quizás de forma atomizada y fragmentada, pero igualmente prolífero en expansión de ciertos valores sociales, en un contexto de creciente imaginario colectivo de individualismo, exitismo y consumismo. (shrink)

This article is an invited comment on the article by George Mandler in the same issue. It is suggested that the latter contains a series of myths that are popular among psychologists. These are that psychology was fragmented into “schools” in the 1920s and 30s and that this led several writers to declare that it was in a state of crisis. It is said to have overcome this crisis by becoming more eclectic and incorporating the best aspects of the various (...) schools. The author suggests that the reality is very different; there is no evidence to suggest that modern psychology has incorporated different aspects of the various schools. It is just as fragmented as it was in the early part of the 20th century, and the crisis literature has continued to the present day. It is suggested that the myths serve the quasi-religious function of keeping faith in the progress of psychology toward “mature science” alive. 2012 APA, all rights reserved). (shrink)

One gains the impression from occasional remarks in the psychiatric literature that there is a feeling of dissatisfaction with the state of flux of the various concepts, serving as tools to help us understand our patients. This paper is submitted as an attempt to point out some of the reasons why psychiatric notions suffer from certain deficiencies. If, for the time being, we set aside the specific psychiatric problems confronting us in our daily work and muse over the structure of (...) our psychological and psychiatric methods of explanation, we might come to the startling conclusion that these methods are quite inadequate. We medical people think in terms of the mechanistic natural sciences, particularly in terms of physics, chemistry and biochemistry. The importance of these auxiliary sciences to our art of healing the sick increases year after year and the outstanding results of chemotherapy, for instance, show how heavily our profession leans on chemistry. Beyond a doubt, the natural sciences are essential to the pursuit and the development of the practice of medicine, nevertheless, the question arises whether psychiatry should be based upon mechanistic methods in approaching our specific material, the human mind. Posed in this fashion, the question implies that psychiatric thinking is basically mechanistic in its general characteristics. I believe that one can prove this thesis on the premise that descriptions and explanations of human behavior are based upon neurological facts and theories. Since the purpose of neurology lies in a different direction than the goal of psychiatry, it was necessary to alter neurological concepts so that they would be more appropriate and fitting to psychic material, and this elaboration upon neurological principles when applied to mental phenomena leads to psychiatric conceptions with inherent deficiencies. (shrink)

May I suggest that there is an angle to the problem of purposeful and non-purposeful behavior which has been overlooked in the recent discussions in this journal, namely, the psychological side of the problem.

In a previous paper it was suggested that specific concepts are needed in the psychological sciences and the basic mental triad was described as a useful tool to further our understanding of mentation. It was stated that the sensori-motor reflex principle cannot describe and explain mental phenomena, because the reflex is basically a mechanistic occurrence, while mental phenomena differ in essence from mechanisms. Since conditioned reflexes can be conceived as sensori-motor reflexes with another, non-mechanistic factor superimposed, similarities and contrasts between (...) reflexes and conditioned reflexes were taken as the material from which one can develop new thoughts about mentation. Reflex shutting of the eyelid, caused by direct contact between cornea and a small, invisible foreign body was compared with and contrasted to shutting the eye before a large, visible object thrusting toward the eye. It was shown that reflexes occur in response to a stimulus after the stimulus has been applied, while conditioned reflexes seem to anticipate the stimulus. This was taken as evidence that conditioned reflexes have a protensive character, have a relationship to the future, which sensori-motor reflexes lack. This difference in time relationship was developed into the statement that the difference between mechanisms and mental phenomena lies in their different relationship to the future. The need for specific concepts to describe mental phenomena stems from the inability of the reflex principle to deal with the protensive tendency of mental phenomena and to fill this need the concept of the basic mental triad was offered. This principle consists of three interdependent, interwoven phases: the triad connects with the past through condensation of some of the subject's past experience into a vaguely formed conglomerate; it connects with the future by projecting the condensed past into the future; the central phase of the triad is the act within the present instant, where a synthesis of past, present and future is accomplished. (shrink)

Measuring time is expressing temporal relationships between objects in terms of spatial relationships with the aid of geometric points, straight lines and clocks. The concepts, point and line, are abstracted from the concrete substratum of sensory experience. This process of abstraction is integrated with the psychological processes which go on within an observer who is reading a clock. The analysis of clock-reading from a psychological point of view points up the necessity to differentiate between two modalities of time: objective time, (...) or, time relationships between objects and which can be expressed in terms of space with point, line and clock; and subjective time, or, the time structure of the human individual in which region point and line are irrelevant concepts. From this irrelevance of point and line it follows that subjective time cannot be measured. (shrink)

A recent surge of research has begun to examine music participation and well-being; however, a particular challenge with this work concerns theorizing around the associated well-being benefits of musical participation. Thus, the current research used Self-Determination Theory to consider the potential associations between basic psychological needs (competence, relatedness, and autonomy), self-determined autonomous motivation, and the perceived benefits to well-being controlling for demographic variables and the musical activity parameters. A sample of 192 Australian residents (17-85, Mage = 36.95), who were currently (...) participating in a musical activity at the time, completed an online questionnaire. Results indicated that females were more likely to perceive benefits to their well-being; and that how important an individual considers music in their life was positively related to perceived well-being. Importantly, the analyses also revealed that the basic needs of competency and relatedness were related to overall perceived well-being as well as specifically social, cognitive, and esteem dimensions of well-being. Autonomous motivation demonstrated significant associations with both an overall well-being score as well as four of five specific well-being subscales measured. Collectively, the findings indicate that Self-Determination Theory offers a useful theoretical framework to understanding the relationship between musical participation and well-being. Further, the pattern of findings reiterates the positive associations between musical participation and one’s psychosocial well-being, with broad implications for people involved in the facilitation of musical activity. (shrink)

Animal data suggest that jet fuels such as JP-8 are associated with hearing deficits when combined with noise and that the effect is more pronounced than with noise exposure alone. Some studies suggest peripheral dysfunction while others suggest central auditory dysfunction. Human data are limited in this regard. The aim of this study was to investigate the possible chronic adverse effects of JP-8 combined with noise exposure on the peripheral and central auditory systems in humans. Fifty-seven participants who were current (...) personnel from the Royal Australian Air Force were selected. Based on their levels of exposure to jet fuels, participants were divided into three exposure groups. Groups were also categorised based on their noise exposure levels. All participants were evaluated by tympanometry, pure-tone audiometry, distortion product otoacoustic emissions, auditory brainstem response, words-in-noise, compressed speech, dichotic digit test, pitch pattern sequence test, duration pattern sequence test and adaptive test of temporal resolution. All auditory tests were carried out after the participants were away from the Air Force base for a minimum of two weeks, thus two weeks without jet fuel and noise exposure. Jet fuel exposure was significantly associated with hearing thresholds at 4 and 8 kHz; average hearing thresholds across frequencies in the better ear; DPOAEs at 2.8, 4 and 6 kHz; ABR wave V latency in the right ear; compressed speech and words-in-noise. Further analyses revealed that participants with low exposure level to jet fuels showed significantly better results for the aforementioned procedures than participants with moderate and high exposure levels. All results were controlled for the covariates of age and noise exposure levels. The results suggest that jet fuel exposure, when combined with noise exposure, has an adverse effect on audibility in humans. Taking all the test results into consideration, jet fuel exposure combined with noise exposure specifically seems to affect the peripheral hearing system in humans. (shrink)

The aim of this paper is to evaluate the extent of the practice of using informal payments for accessing the services of public clinics or hospitals across Europe and to explain the prevalence of this corrupt practice using the framework of institutional theory. To achieve this, a multi-level mixed-effect logistic regression on 25,744 interviews undertaken in 2020 with patients across 27 European Union countries is conducted. The finding is that the practice of making informal payments remains a prevalent practice, although (...) there are large disparities in the usage of this practice in different European countries. However, informal payments by patients are more likely when there is a lower institutional trust and a higher degree of asymmetry between formal and informal institutions. The resultant proposal is that policy makers need to address the institutional environment to tackle such informal payments. How this can be achieved is outlined. (shrink)

Current debates over so-called ‘scientific imperialism’, on one plausible reading, explore significant general issues about the proper boundaries between distinct disciplines. They raise questions about whether some forms of territorial expansion by scientific disciplines into other domains of inquiry are undesirable. Clearly there is a strong normative undercurrent here, as the use of the pejorative term ‘imperialism’ would indicate. However, we face a genuine puzzle here: why should we regard some forms of expansion as illegitimate? Why should any particular boundaries (...) between various disciplines be regarded as sacrosanct? In response we note that one striking feature of the examples upon which opponents of scientific imperialism focus (such as the use of economics for sociological explanations) is that that they involve cases where folk conceptions of morality and philosophical anthropology appear to be threatened. We suggest that rather than seeking a more general pluralist account of the proper boundaries between disciplines, we should consider the epistemic and normative implications of particular expansions. (shrink)

Editors' Introduction to the special issue of Research in Ethical Issues in Organisations, the proceedings of the 27th Annual Conference of the Australian Association of Professional and Applied Ethics, hosted by the Discipline of Philosophy and Religious Studies at the University of New England in 2020.

Conspiracy theories (CTs) are widespread ways by which people make sense of unsettling or disturbing cultural events. Belief in CTs is often connected to problematic consequences, such as decreased engagement with conventional political action or even political extremism, so understanding the psychological and social qualities of CTs belief is important. CTs have often been understood to be “monological”, displaying the tendency for belief in one conspiracy theory to be correlated with belief in (many) others. Explanations of monologicality invoke a nomothetical (...) or “closed” mindset whereby mutually supporting beliefs based on mistrust of official explanations are used to interpret public events as conspiracies, independent of the facts about those events (which they may ignore or deny). But research on monologicality offers little discussion of the content of monological beliefs and reasoning from the standpoint of the CT believers. This is due in part to the “access problem” (Wood & Douglas, 2015): CT believers are averse to being researched because they often distrust researchers and what they appear to represent. We used several strategies to address the access problem, and investigated the symbolic resources underlying CTs by reconstructing a conspiracy worldview - a set of beliefs held by CT believers about important dimensions of ontology, epistemology, and human agency. To do this, we analysed media documents, conducted field observation, and engaged in semi-structured interviews,. We describe six main dimensions of a conspiracy worldview: Views of the nature of reality, the self, the outgroup, the ingroup, action, and the future. We also describe a typology of five types of CT believers, which vary according to their positions on each of these dimensions. Our findings converge with prior explorations of CT beliefs but also revealed novel aspects: A sense of community among CT believers, a highly differentiated representation of the outgroup, a personal journey of conversion, variegated kinds of political action, and optimistic belief in future change. These findings are at odds with the typical image of monological CT believers as paranoid, cynical, anomic and irrational. For many, the CT worldview may rather constitute the ideological underpinning of a nascent pre-figurative social movement. (shrink)

For decades, scholars have debated the corporate objective. Scholars have either advocated a corporate objective focused on generating value for shareholders or creating value for multiple groups of stakeholders. Although it has been established that the corporate objective can shape many aspects of the corporation—including culture, compensation, and decision making—to date, scholars have not yet explored its psychological impact; particularly, how the corporate objective might influence employee well-being. In this article, we explore how two views of the corporate objective affect (...) employee self-determination, a key component of overall psychological need satisfaction and well-being. We hypothesize that a corporate objective based on creating value for multiple stakeholders will increase employee psychological need satisfaction as compared to one focused on creating value for only shareholders. Across four experimental studies and one field survey, we find consistent support for our hypotheses and test three facets of a stakeholder-focused corporate objective. Theoretical implications and future research directions are discussed. (shrink)

There is growing appreciation of the challenges posed by our current economic activity in terms of the natural environment. Increasingly, people have come to appreciate that business must not only be more aware of its environmental impact, but also must be more environmentally sustainable in its core operations. Academic theories of management influence managerial practice. They clarify what is important to the corporation, and where managers and employees should direct their attention. The focus of this paper is to explore the (...) extent to which three possible managerial mindsets—shareholder value maximization, stakeholder value maximization, and the triple bottom line—may either enhance or inhibit the ability of corporations to manage in an environmentally sustainable way. We discuss the implications of each of these mindsets and highlight their relative strengths and weaknesses, noting that all three hold promise, but each has limitations in enabling managers to operate sustainably. (shrink)

The dialogue about the future of health care in the US has been impeded by flawed conceptions about medicine and business. The present paper re-examines some of the underlying assumptions about both medicine and business, and uses more nuanced readings of both terms to frame debates about the ACA and the emerging health care environment.

Many observers claim that business has become a powerful force in medicine and that the future of health care cannot escape that reality, even though some scholars lament it. The U.S. recently experienced the most devastating recession since the Great Depression. As health care costs rise, we face additional pressure to rein in health care spending. We also have important new legislation that could well mark a significant shift in how health care is provided and who has access to care, (...) namely the Affordable Care Act. These changes underscore the need to bring new thinking to the conversation about health care and to move beyond conceptual and practical obstacles that inhibit our progress.In this paper we do not to claim to have solutions. Rather, our aim is to try to identify some obstacles to fostering a better conversation about the future of health care and to envisioning a better health care system. (shrink)

Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked capacity, obtaining consent later when or if capacity returned or a proxy was found. From a total of 233 patients 23 patients lacked capacity as judged by our informal capacity judgment and 210 did not. Of those who lacked capacity, 13 agreed to enter in the study. Six of them regained capacity later. When these (...) 13 participants were excluded from analysis, significant findings were no longer evident. These results show that by the inclusion of subjects who lacked capacity the results of analyses of the condition from whish they suffer are altered. We suggest that this approach to the study of delirium is more ethical than the usual system of strict exclusion of people who lack capacity to give consent and for whom assent is not available. (shrink)

The intrinsic merit of Northoff's model lies primarily in the fact that it integrates data concerned with different levels of organization of the brain. This approach implicitly argues against reductionism, although, apparently, its rather simplistic assumption gives too many degrees of freedom. In considering that a symptom from two different syndromes indicates a common neural alteration, we grossly disregard neural plasticity.

The target article is an elegant synthesis of the developmental and functional data and views on the evolutionary origin of the mammalian isocortex, integrating results from cell and molecular biology, experimental neuroanatomy, and chemoarchitectonic studies. Complementarily, we give here an account of two modes of isocortical evolution (prosomere reshuffling and invention) in terms of costs of radiation and neural tissue.

How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on "Microbiota, Symbiosis and Individuality: Conceptual and Philosophical Issues" (July 2019), which was supported by a European Research Council starting grant project "Immunity, DEvelopment, and the Microbiota" (IDEM). The summer school centered around interdisciplinary group work on four facets of microbiota research: holobionts, individuality, causation, and human health. The conceptual discussion of cutting-edge empirical research provided new insights into microbiota and highlights the value of (...) incorporating into meetings experts from other disciplines, such as philosophy and history of science. (shrink)

This white paper outlines the plans of the History Philosophy Culture Working Group of the Next Generation Event Horizon Telescope Collaboration.